The MycoSynVac project aims at using cutting-edge synthetic biology methods to engineer Mycoplasma pneumoniae as a universal chassis for vaccination. We will (1) modify existing methods of genome transplantation used for Mycoplasma species, (2) develop serum-free medium for scale-up in bioreactors and (3) analyze how to bring the product to market after efficacy of the vaccine has been shown in animal studies, ultimately to fight Mycoplasma infections in farm animals.